Before running YoYotta check how to Install macFuse on the Mac.
Extracting metadata from some MXF files requires macOS 10.15.7 or macOS Big Sur and Apple Pro Video Formats 2.2.1 or newer to be installed
With Big Sur if using an LTO drive with a ATTO SAS interface, then you will need to Install ATTO drivers.
With Big Sur if using an mLogic LTO drive then you will need to Install mTape.
If using an LTO drive or library click the LTFS button and YoYotta will check and download the LTFS frameworks.
Then run YoYotta and click the at the bottom of the panel to step through the main parts of the interface.